Pathophysiology, clinical features and radiological findings of differentiation syndrome/all-trans-retinoic acid syndrome

Table 1 Signs and symptoms

Differentiation syndrome: Sign and symptoms
Elevated white blood cell count	Weight gain > 5 kg
Dyspnea	Bone pain
Respiratory distress	Headache
Fever	Hypotension
Pulmonary edema	Congestive heart failure
Pulmonary infiltrates	Acute renal failure
Pleural and pericardial effusion	Hepatotoxicity