Impact of dose calculation algorithm on radiation therapy

Table 1 Calculated percent mean tumor control probability values (ranges in parentheses) for all algorithms as a function of planning target volume volume

PTV bins (cm3)	Mean PTV volume(range, cm3)	n	EPL-1D	EPL-3D	AAA	CCC	Acuros	MC
4 ≤ v < 10	7.8 (4.8-9.9)	15	100.0 (100-100)	99.9 (99.6-100)	93.1 (76.3-99.8)	91.3 (63.0-99.9)	91.8 (60.8-99.8)	90.5 (51.1-99.9)
10 ≤ v < 20	15.0 (10.4-19.8)	27	100.0 (99.8-100)	99.9 (99.5-100)	91.3 (61.7-100)	91.3 (50.4-100)	91.4 (65.4-99.9)	91.1 (53.2-100)
20 ≤ v < 30	24.3 (20.4-29.6)	29	98.5 (99.8-100)	98.9 (77.6-100)	92.7 (74.9-99.9)	90.5 (46.4-99.9)	90.9 (65.1-99.9)	91.1 (48.4-99.9)
30 ≤ v < 40	34.9 (30.2-39.8)	18	99.8 (97.4-100)	99.6 (98.2-100)	92.0 (63.4-99.9)	92.1 (69.7-99.9)	90.9 (61.6-99.8)	92.4 (56.3-99.9)
40 ≤ v < 60	47.3 (40.2-58.4)	17	99.5 (93.1-100)	99.1 (95.6-100)	92.6 (78.6-99.9)	91.4 (64.4-99.9)	93.6 (77.6-99.9)	92.3 (63.6-99.9)
60 ≤ v < 100	78.0 (60.4-95.9)	16	99.5 (95.6-100)	99.0 (95.8-100)	92.7 (70.7-99.8)	92.8 (66.2-99.9)	93.4 (70.4-99.8)	94.7 (74.6-99.9)
V ≥ 100	162.4 (100.5-360.2)	11	99.2 (96.1-99.9)	98.7 (95.0-100)	96.3 (89.9-100)	95.6 (91.6-99.8)	95.3 (83.0-99.9)	97.1 (88.8-99.9)

PTV: Planning target volume; EPL-1D: 1-D equivalent path-length (pencil beam-type); EPL-3D: 3-D equivalent-path-length (pencil beam-type); AAA: Anisotropic analytical algorithm; CCC: Collapsed cone convolution-superposition; Acuros: Acuros AXB; MC: Monte Carlo. (Cited from Chetty et al[30] 2013).