Impact of the arterial input function on microvascularization parameter measurements using dynamic contrast-enhanced ultrasonography

Figure 1 Graph displaying an example of a time intensity curve with four of its seven associated microvascularization parameters: the peak intensity, the time to peak intensity, the slope coefficient of the wash-in and the full width at half maximum. The three other microvascularization parameters extracted from the time intensity curve are the area under the curve, the area under the wash-in and the area under the wash-out. WI: Wash-in; FWHM: The full width at half maximum; PI: The peak intensity; I_max: Maximal intensity value; I₀; Initial intensity value; T_L is the latency time and is defined as the time at the intersection between y = I₀ and the tangent at T_max/2 where T_max is the time associated with I_max.