Image of tumor metastasis and inflammatory lymph node enlargement by contrast-enhanced ultrasonography

Table 1 List of experimental models

Model No. #	Implanting	Days after implanting	Size of lymph node	Imaging findings in B mode	Imaging findings in contrast enhanced ultrasonography
1	VX2	28	18 × 11	Hypoechoic	Only the periphery was enhanced
					The central area was notably defective
2	VX2	28	18 × 10	Iso-hypoechoic	Only part of the periphery was enhanced. Most sites were not enhanced
3	VX2	21	15 × 10	Isoechoic	A comparatively small defect was seen internally
4	VX2	35	16 × 10	Hypoechoic	A comparatively small defect was seen internally
5	VX2	21	17 × 6	Hypoechoic	A comparatively small defect was seen internally
6	VX2	7	12 × 7	Iso-hypoechoic	The entire lymph node could be enhanced
7	E. coli	28	17 × 8	Iso-hypoechoic	The entire lymph node was enhanced (a defective star-like image was seen)
8	E. coli	3	8 × 3	Isoechoic	The entire lymph node was enhanced
9	E. coli	7	13 × 5	Iso-hypoechoic	The entire lymph node was enhanced
10	E. coli	3	9 × 3	Hypoechoic	The entire lymph node was enhanced
11	E. coli	3	8 × 3	Isoechoic	The entire lymph node was enhanced

The list of the tumor-induced and inflammation-induced lymph node enlargement models is shown. Models 1 to 6 are tumor-induced lymph node enlargement that was obtained by implanting VX2 tumor. Models 7 to 11 are inflammation-induced lymph node enlargement that was obtained by implanting Escherichia coli (E. coli).