Theranostic applications: Non-ionizing cellular and molecular imaging through innovative nanosystems for early diagnosis and therapy

Figure 2 Example of automatic detection of accumulated Silica Nanoparticles. A: Scheme of the analyzed phantom; B: B-mode image of a control phantom with indication of the chosen ROI; C-E: Images of the analyzed ROIs with automatic detection results displayed in blue, red, and green for 150-nm, 320-nm, and 650-nm SiNPs, respectively. The sensitivity of the developed method for automatic nanoparticle detection had a maximum of 71% with 320-nm particles, whereas it was lower with both larger and smaller particles (sensitivity of 63% and 18%, respectively).