Ultrasomics in liver cancer: Developing a radiomics model for differentiating intrahepatic cholangiocarcinoma from hepatocellular carcinoma using contrast-enhanced ultrasound

Table 2 Radiomic features in the radiomic analysis

Types	Features
Shape (n = 9)	Elongation, MajorAxisLength, MaximumDiameter, MeshSurface, MinorAxisLength, Perimeter, PerimeterSurfaceRatio, PixelSurface, Sphericity
First order (n = 18)	10Percentile, 90Percentile, Energy, Entropy, InterquartileRange, Kurtosis, Maximum, MeanAbsoluteDeviation, Mean, Median, Minimum, Range, RobustMeanAbsoluteDeviation, RootMeanSquared, Skewness, TotalEnergy, Uniformity, Variance
GLCM (n = 22)	Autocorrelation, JointAverage, ClusterProminence, ClusterShade, ClusterTendency, Contrast, Correlation, DifferenceAverage, DifferenceEntropy, DifferenceVariance, JointEnergy, JointEntropy, Imc1, Imc2, Idm, Idmn, Id, Idn, InverseVariance, MaximumProbability, SumEntropy, SumSquares
GLRLM (n = 16)	GrayLevelNonUniformity, GrayLevelNonUniformityNormalized, GrayLevelVariance, HighGrayLevelRunEmphasis, LongRunEmphasis, LongRunHighGrayLevelEmphasis, LongRunLowGrayLevelEmphasis, LowGrayLevelRunEmphasis, RunEntropy, RunLengthNonUniformity, RunLengthNonUniformityNormalized, RunPercentage, RunVariance, ShortRunEmphasis, ShortRunHighGrayLevelEmphasis, ShortRunLowGrayLevelEmphasis
GLSZM (n = 16)	GrayLevelNonUniformity, GrayLevelNonUniformityNormalized, GrayLevelVariance, HighGrayLevelZoneEmphasis, LargeAreaEmphasis, LargeAreaHighGrayLevelEmphasis, LargeAreaLowGrayLevelEmphasis, LowGrayLevelZoneEmphasis, SizeZoneNonUniformity, SizeZoneNonUniformityNormalized, SmallAreaEmphasis, SmallAreaHighGrayLevelEmphasis, SmallAreaLowGrayLevelEmphasis, ZoneEntropy, ZonePercentage, ZoneVariance
GLDM (n = 14)	DependenceEntropy, DependenceNonUniformity, DependenceNonUniformityNormalized, DependenceVariance, GrayLevelNonUniformity, GrayLevelVariance, HighGrayLevelEmphasis, LargeDependenceEmphasis, LargeDependenceHighGrayLevelEmphasis, LargeDependenceLowGrayLevelEmphasis, LowGrayLevelEmphasis, SmallDependenceEmphasis, SmallDependenceHighGrayLevelEmphasis, SmallDependenceLowGrayLevelEmphasis
NGTDM (n = 5)	Busyness, Coarseness, Complexity, Contrast, Strength

Imagetype: Original, Log-sigma-2-0-mm-3D, Log-sigma-3-0-mm-3D, Log-sigma-4-0-mm-3D, Wavelet-H, wavelet-L, lbp-2D, square, squareroot, logarithm, exponential. GLCM: Gray Level Concurrence Matrix; GLDM: Gray Level Dependence Matrix; GLRLM: Gray Level Run-Length Matrix; GLSZM: Gray Level Size-one Matrix; NGTDM: Neighborhood Gray-Tone Difference Matrix.