Chronic thromboembolic pulmonary hypertension is associated with a loss of total lung volume on computed tomography

Table 3 Lung volume and heart-size change in patients with chronic thromboembolic pulmonary hypertension and in the control group

Parameter	CTEPH, n = 15	Control, n = 45	P value
Total lung volume change in mL, mean (95%CI)	176 (13, 468)	39 (-228, 252)	0.01a
Right lung volume change in mL, mean (95%CI)	120 (47, 292)	4 (-121, 126)	0.007b
Right upper + middle lobe lung volume change in mL, mean (95%CI)	35 (-26, 91)	-7 (-46, 46)	0.9
Right lower lobe lung volume change in mL, mean (95%CI)	85 (19, 167)	-9 (-66, 83)	0.01a
Left lung volume change in mL, mean (95%CI)	23 (-37, 214)	33 (-109, 99)	0.1
Left upper lobe lung volume change in mL, mean (95%CI)	13 (-31, 81)	1 (-44, 53)	0.4
Left lower lobe lung volume change in mL, mean (95%CI)	40 (-23, 112)	9 (-59, 63)	0.1
Cardiac cross-sectional area change in cm2, mean (95%CI)	19 (4, 25)	-0.3 (-2, 3)	0.0002c

^aP < 0.05.

^bP < 0.01.

^cP < 0.001. CI: Confidence interval; CTEPH: Chronic thromboembolic pulmonary hypertension.