Meta-Analysis
Copyright ©The Author(s) 2023.
World J Radiol. Nov 28, 2023; 15(11): 324-337
Published online Nov 28, 2023. doi: 10.4329/wjr.v15.i11.324
Table 2 Description of the studies included in the meta-analysis
Ref.
Type of study
Patients enrolled
Mean/median age (yr)
Male (%)
LGE present, n (%)
Mean/Median Follow-Up Time
Endpoint included in analysis
Mean/median LVEF (%)
Mean/median LVEDVi (mL/m2)
Halliday et al[6], 2019Prospective874LGE negative: 51.0 ± 15.1; LGE extent (0.00%-2.55%): 52.8 ± 14.4; LGE extent (2.55%-5.10%): 53.7 ± 14.6; LGE extent (> 5.10%): 56.2 ± 14.6588 (67.3)300 (34.3)4.9 yr (range, 3.5-7.0 yr)All cause mortality; arrhythmic events: SCD and aborted SCD.39 (range, 29-50)LGE negative: 126.3 ± 36.6; the extent of LGE (0.00-2.55%): 147.9 ± 46.1; the extent of LGE (2.55%-5.10%): 142.8 ± 49.8; the extent of LGE (> 5.10%): 135.5 ± 37.3
Gulati et al[2], 2013Prospective47251.1 ± 14.7324 (68.6)142 (30.1)5.3 yr (range, 31 d-11.0 yr)Arrhythmic events: SCD and aborted SCD; all cause mortality37±13135.1 ± 44.3
Behera et al[9], 2020Retrospective112LGE negative: 45.5 (range, 33.0-58.7); LGE positive: 40.0 (range, 24.5-54.5)LGE negative: 42 (61.8); LGE positive: 30 (68.2)44 (39.3)745 ± 320 dComposite endpoint: All-cause mortality, resuscitated cardiac arrest, sustained VT/appropriate ICD shock, HF hospitalizationLGE negative: 31.5 (range, 28.0-36.2); LGE positive: 32.5 (range, 27.0-41.0)LGE negative: 104.0 (range, 77.0-125.0); LGE positive: 137.0 (range, 87.5-225.2)
Tateishi et al[10], 2015Prospective20750 ± 16165 (80)105 (50.7)44 mo (range, 23-62 mo)Composite endpoint: Cardiac death, cardiac transplantation, LV assist device implantation, appropriate ICD discharge for VT or VF, and rehospitalisation for HF27 ± 11143 ± 57
Lehrke et al[11], 2011Prospective18451.55 ± 1.1138 (75)72 (39.1)685 ± 30 dComposite endpoint: Cardiac death, hospitalisation for decompensated HF, or appropriate ICD dischargeLGE negative: 44 (range, 33.1-50.9); LGE positive: 31 (range, 20.9-42.2)LGE negative: 109 (range, 92.7-137.6); LGE positive: 133 (range, 116-161)
Perazzolo et al[7], 2014Prospective137No arrhythmic events: 47 (range, 37-60); arrhythmic events: 59 (range, 43-70)108 (78.8)76 (55.5)3 yr (range, 31 d-9.6 yr)Arrhythmic events: SCD, cardiac arrest due to VF, sustained VT, or appropriate ICD intervention.No arrhythmic events:33 (range, 28-40); arrhythmic events: 30 (range, 29-40)No arrhythmic events: 109 (range, 87-140); arrhythmic events: 123 (range, 105-143)
Neilan et al[12], 2013Prospective16255 ± 14106 (65)81 (50)29 ± 18 moComposite endpoint: Cardiovascular death and appropriate ICD therapy; arrhythmic events: ATP, ICD discharge, and non-heart failure cardiovascular death28 ± 9140 ± 50
Yamada et al[13], 2014Prospective5755 ± 1340 (70.2)25 (44)71 ± 32 moComposite endpoint: Cardiac death, hospitalization for decompensated HF, or documented lethal arrhythmia, including VT and VFLGE negative: 36 ± 13; LGE positive: 30 ± 11LGE negative: 120 ± 39; LGE positive: 141 ± 47
Buss et al[14], 2015Prospective21052 ± 15159 (76)79 (38)5.3 yrComposite endpoint: Cardiac events together with the occurrence of hospitalization due to congestive HF36.1 ± 13.8132 ± 48
Mikami et al[15], 2016Prospective11857 ± 1468 (58)66 (56)2.1 ± 1.3 yrComposite endpoint: Cardiac mortality or appropriate ICD therapy; arrhythmic events: Appropriate ICD therapy or SCD32 ± 12119 ± 42
Puntmann et al[16], 2016Prospective63750 (range, 37-76 yr)395 (62)171 (27)22 mo (range, 19-25 mo)All cause mortality47 (range, 29-50)109 (range, 89-132)
Masci et al[17], 2012Prospective12559 ± 1482 (65.6)50 (40)14.2 mo (range, 6.5–28.8 mo)Composite endpoint: Cardiac death and HF hospitalization33 ± 10LGE negative: 124 ± 35; LGE positive: 140 ± 39
Šramko et al[8], 2013Prospective42Idiopathic: 45 ± 12; inflammatory: 42 ± 830 (71.4)28 (66.7)25 ± 9 moComposite endpoint: Cardiac death, urgent heart transplantation, and hospitalization for worsening HFIdiopathic DC: 22 ± 11; Inflammatory DC: 21 ± 9Idiopathic: 137 ± 39; Inflammatory: 148 ± 46
Amzulescu et al[20], 2015Prospective16255 ± 15102 (63.0)63 (39)3.4 yr (range, 1.5-6.3 yr)Composite endpoint: Cardiovascular death, heart transplantation, LV assist device implantation, resuscitated cardiac arrest, and appropriate device shocks24.6 ± 8.4161.6 ± 52
Alba et al[21], 2020Retrospective167256 ± 141185 (70.9)650 (39)2.3 yr (range, 1.0-4.3 yr)Composite endpoint: All-cause mortality, heart transplantation, or left ventricular assist device implant; arrhythmic events: SCD or appropriate ICD shock33 ± 11118 ± 27
Xu et al[18], 2021Prospective41248.0 ± 14.4300 (72.8)201 (48.8)28.1 mo (range, 19.3-43.0 mo)Composite endpoint: All-cause mortality and HF readmission; all-cause mortality23.7 ± 9.8185.6 ± 58.9
Barison et al[19], 2020Prospective18366 (range, 56-73 yr)134 (73)116 (63)30 mo (range, 10-65 mo)Composite endpoint: Appropriate ICD shock and cardiac death; arrhythmic events: appropriate ICD shock24 (range, 21-31)143 (range, 120-168)
Halliday et al[4], 2017Prospective39949.9 ± 15.3254 (63.7)101 (25.3)4.6 yr (range, 3.5-7.0 yr)Arrhythmic events: SCD or Aborted SCD49.6 ± 4.9111.1 ± 19.4
Di Marco et al[22], 2021Retrospective116558 (range, 48-68)768 (65.9)486 (41.7)36 mo (range, 20-58 mo)Arrhythmic events: Appropriate ICD therapies, sustained VT, resuscitated cardiac arrest, and sudden death39 (range, 30-46)118 (range, 99-142)