Magnetic resonance imaging ancillary features used in Liver Imaging Reporting and Data System: An illustrative review

Table 2 Hepatocellular carcinoma specific features suggesting malignancy

Feature	Critical details
Intra-lesional fat	Characteristic of early HCC; Exception: Steatohepatitic variant of HCC, which may exhibit marked intralesional fat even if they represent progressed cancer
Nodule-in-nodule architecture	“Subnodule” corresponding to the HCC typically shows enhancement characteristics similar to other HCCs; “Parent” nodule is typically hyperintense on T1-WI, hypointense on T2-WI and hypo- or isoenhancing on the arterial phase (atypical of HCC)
Mosaic architecture	Extremely unusual in other tumors; Uncommon in small HCCs; May be helpful for the diagnosis of large hypovascular HCCs
Blood products	Associated with HCC expansion; Previous biopsy should be discarded

HCC: Hepatocellular carcinoma.