Takotsubo cardiomyopathy: Pathophysiology and role of cardiac biomarkers in differential diagnosis

doi:10.4330/wjc.v9.i9.723

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World Journal of Cardiology

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World J Cardiol. Sep 26, 2017; 9(9): 723-730
Published online Sep 26, 2017. doi: 10.4330/wjc.v9.i9.723

Table 2 Natriuretic peptide/cardiac myonecrosis marker ratio in takotsubo cardiomyopathy and acute coronary syndrome

Ref.	Biomarker and time of collection	Takotsubo cardiomyopathy		Acute coronary syndrome
Frölich et al[36]	NT-proBNP (peak)	Cutoff NT-proBNP/TnT to differentiate TC and NSTEMI		Cutoff NT-proBNP/TnT to differentiate TC and STEMI
	TnT (peak)	5000		2889
Lahoti et al[37]	NT-proBNP (mean)	NT-proBNP/TnT		NT-proBNP/TnT (STEMI)
	TnT (peak)	5154 ± 1891.2		183 ± 128.9
Randhawa et al[38]	First simultaneous BNP and TnT	BNP/TnT	BNP/CKMB	BNP/TnT (AMI)	BNP/CKMB (AMI)
		1292 (443.4-2657.9)	28.44 (13.7-94.8)	226.9 (69.9-426.3)	3.63 (1.1-10.0)
Doyen et al[39]	BNP (admission)	BNP/TnI		BNP/TnI (NSTEMI)	BNP/TnI (STEMI)
	TnI (peak)	642 (331.8-1226.5)		184.5 (50.5-372.3)	7.5 (2.0-29.6)

BNP: Brain natriuretic peptide; NT-proBNP: N-terminal proBNP; TnT: Troponin T; TnI: Troponin I; NSTEMI: Non-ST elevation myocardial infarction; STEMI: ST elevation myocardial infarction; CKMB: Creatine kinase-MB fraction.

Citation: Gopalakrishnan P, Zaidi R, Sardar MR. Takotsubo cardiomyopathy: Pathophysiology and role of cardiac biomarkers in differential diagnosis. World J Cardiol 2017; 9(9): 723-730
URL: https://www.wjgnet.com/1949-8462/full/v9/i9/723.htm
DOI: https://dx.doi.org/10.4330/wjc.v9.i9.723