Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner

Figure 7 Interleukin-19 and interleukin-20R expression in male and female cardiac fibroblasts and myocytes. A: Both male and female Cfib and CM express IL-19, with no differences between sexes or cell types; B: Both Cfib and CM express IL-20Rα, with higher expression in CM than Cfib, as evident by the lower delta Ct. Male CM tended to express higher IL-20Rα than female CM (P = 0.06); C: Both Cfib and CM express IL-20Rβ, with no differences between cell types or sex; D: The ratio of IL-20Rα/β was significantly higher in CM than Cfib. IL-19 and IL-20R expression were assessed by qRT-PCR and normalized to the housekeeping gene 18S. Data are expressed as mean ± SEM and assessed by 2-way ANOVA; n = 7-8 mice per group. Cfib: Cardiac fibroblasts; CM: Cardiac myocytes.