Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner

Figure 3 Kaplan-Meier survival curve of dominant negative cyclic AMP response-element binding protein and double transgenic male and female mice. IL-19 knockout in the setting of dnCREB accelerates male mouse mortality, while not affecting female dnCREB survival. No mortality was observed in Control or IL-19 KO mice during this period. Log-rank analyses were performed to compare survival between groups. ^aP < 0.05 vs female DTG, female dnCREB, and male DTG; n = 7-10 mice per group. dnCREB: Do-minant negative cyclic AMP response-element binding protein; DTG: Double transgenic.