Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner

Figure 2 Activation of signal transducer and activator of transcription 3 in the dominant negative cyclic AMP response-element binding protein model of female-dominant heart failure. A: Male and female dnCREB mice show attenuated STAT3 activation compared to controls; B: Representative immunoblotting images. Activation of STAT3 was assessed by immunoblotting of phospho STAT3/total STAT3. Data are expressed as mean ± SEM and analyzed by 2-way ANOVA. All four conditions were run on the same gel, and non-essential lanes were removed for generation of the representative images. ^aP < 0.05, n = 2-6 mice per group. a: Significant effect of genotype. dnCREB: Do-minant negative cyclic AMP response-element binding protein; STAT3: Signal transducer and activator of transcription 3.