Cardiovascular magnetic resonance imaging assessment of outcomes in acute myocardial infarction

Table 16 Key studies illustrating the independent predictive value of cardiovascular magnetic resonance markers for left ventricular remodelling

CMR marker	Ref.	Year	n	CMR quantification	Main findings	Acute CMR time	Follow-up CMR time
IS	Husser et al[33]	2012	304	2SD	IS extent IP for LVR in model with LVEF, IS, LV volumes, MVO	6 d	189 d
IS	Monmeneu et al[91]	2012	118	2SD	Number of segments > 50% transmurality IP for LVR	6 d	6 mo
IS	Wu et al[94]	2008	122	Manual	IS extent at 2 d only IP for LVEF and LVR	2 d	4 mo
IS	Hombach et al[6]	2005	110	Manual	IS extent at 6 d was an IP for LVR in model with MVO, % transmurality	6 d	225 d
L-MVO	Weir et al[112]	2010	100	Manual	L-MVO extent was only IP of LVR in model with TIMI post PCI, E-MVO, IS	4 d	6 mo
L-MVO	Hombach et al[6]	2005	110	Manual	L-MVO extent IP of LVR in model with baseline IS, infarct transmurality	6 d	225 d
IMH	Carrick et al[74]	2016	245	T2*	IMH strongest IP of LVR in model with patient/angio characteristics, LVEDVI	3 d	7 mo
IMH	Husser et al[33]	2012	304	T2w-TSE	IMH strongest IP for LVR in model with LVEF, IS, LV volumes, L-MVO	6 d	189 d
MSI	Monmeneu et al[91]	2012	118	2SD LGR/STIR	MSI univariate but not IP of LVR in model with IS, LVESVI, segments > 50%	6 d	6 mo
MSI	Masci et al[14]	2011	260	2SD STIR, 5SD LGE	MSI univariate predictor of LVR and final LVEF. However not IP of either	1 wk	4 mo
MSI	Masci et al[26]	2010	137	> SD STIR, 5SD LGE	MSI strongest IP for LVR. However IS and MSI and IS and AAR correlated	1 wk	4 mo
T1	Carrick et al[177]	2016	300	T1 map, 2SD STIR, 5SD LGE	Infarct core native T1 inverse relationship with LVR (OR 0.91 per -10 ms T1)	2 d	6 mo

Criteria: Individual studies with n≥ 100 and follow-up CMR ≥ 3 mo post-PPCI. IS: Infarct size; L-MVO: Late microvascular obstruction; IMH: Intramyocardial haemorrhage; MSI: Myocardial salvage index; SD: Standard deviations; STIR: T2-weighted short-tau inversion recovery; LGE: Late gadolinium enhancement; IP: Independent predictor; LV: Left ventricular; LVEF: Left ventricular ejection fraction; AAR: Area at risk; LVEDVI: Left ventricular end-diastolic volume; CMR: Cardiovascular magnetic resonance.