Meta-Analysis
Copyright ©The Author(s) 2017.
World J Cardiol. Dec 26, 2017; 9(12): 830-837
Published online Dec 26, 2017. doi: 10.4330/wjc.v9.i12.830
Table 2 Assessment of quality for the included studies
Newcastle-Ottawa scale for bias assessment for case-controlled studies
Newcastle-Ottawa scale for bias assessmentCariou et al[9], 2008Grmec et al[10], 2009
Selection32
Comparability22
Exposure33
Cochrane Risk of Bias tool for the Randomized controlled study (Cariou et al[11])
EntryJudgementSupport for judgement
Random sequence generation (selection bias)Low riskQuote: “Patients were randomly assigned in a 1:1 ratio to the intervention or the control group”
Allocation concealment (selection bias)Low riskQuote: “Randomization was performed centrally with the use of a computer-generated assignment sequence Intervention assignments were made in permuted blocks of varying size and were stratified according to site”
Blinding of participants and personnel (performance bias)High riskComment: Probably done
Quote: “Single-blinded”; “physicians performing neurological follow-up and final outcome measurement, as well as study administrators and statisticians, were unaware of the intervention assignments”
Comment: Probably done. However, only single blinding performed
Blinding of outcome assessment (detection bias) (patient-reported outcomes)Low riskQuote: “Single-blinded”
Comment: Probably done
Blinding of outcome assessment (detection bias) (mortality)Low riskObtained from medical records; Quote “CPC was assessed by face-to-face contact with patients still hospitalized, and through phone interviews in discharged patients using a standardized protocol”
Review authors do not believe this will introduce bias
Incomplete outcome data addressed (attrition bias) (Longer-term outcomes, > 6 wk)Low risk60 d: 1/234 missing from intervention group (“lost to follow-up”); 0/242 missing from control group
Selective reporting (reporting bias)Low riskA single scale to assess neurological outcomes was used and reported (CPC score)