Erythropoietin therapy after out-of-hospital cardiac arrest: A systematic review and meta-analysis

Table 1 Characteristics of the included studies

Name of study	Cariou et al[9], 2008	Grmec et al[10], 2009	Cariou et al[11], 2016
Study design	Single center, case-control	Single center, case-control	Multicenter, single blind RCT
Total dose of Epo administered	200000 IU	90000 IU	200000 IU
Timing of Epo administration	Immediately after ROSC	Within 1 or 2 min of physician assisted CPR	Immediately after ROSC
No. of participants, n (intervention/control)	18/40	24/48	234/242
Mean age, yr (intervention/control)	59/58	59/60	60.5/58.6
Male gender, n (intervention/control)	16/39	16/34	192/184
Initial rhythm PEA/asystole, n (intervention/control)	2/8	12/17	94/100
Initial rhythm shockable (VF/VT), n (intervention/control)	16/32	12/31	115/110
Perfusing rhythm after bystander defibrillation, n (intervention/control)	0/0	0/0	24/31
Unknown rhythm, n (intervention/control)	0/0	0/0	1/3
Follow-up duration	28 d	Till hospital discharge	60 d

RCT: Randomized control trial; Epo: Erythropoietin; IU: International units; ROSC: Return of spontaneous circulation; CPR: Cardiopulmonary resuscitation; PEA: Pulseless electrical activity; VF: Ventricular fibrillation; VT: Ventricular tachycardia.