Renal sympathetic denervation in therapy resistant hypertension - pathophysiological aspects and predictors for treatment success

Table 2 Blood pressure effects of renal sympathetic denervation

Ref.	Year	Control	n (RDN/control)	Systolic office BP (mmHg)	P-value	Systolic ambulatory BP (mmHg)	P-value
Krum et al[7]	2009	None	50	-22	< 0.001a	NA	NA
Esler et al[11]	2010	RDN vs medical	106 (52/54)	-32 vs 1	< 0.00001b	-11/-7 vs -3/-1	NA
Bhatt et al[8]	2014	RDN vs sham	535 (364/171)	-14 vs -12	0.26b	-6.8 vs -4.8	0.98b
Desch et al[10]	2015	RDN vs sham	71 (35/36, intention to treat)	NA	NA	-8.5 vs -4.7	0.06b
			63 (29/34, per protocol)	NA	NA	-8.3 vs -3.5	0.04b
Rosa et al[13]	2015	RDN vs intensified medical treatment	106 (52/54)	-12 vs -14	< 0.001a/0.60b	-8.6 vs -8.1	< 0.001a/0.87b
Azizi et al[14]	2015	Stepped-care antihypertensive treatment with vs without RDN	106 (53/53)	-15 vs -9	0.15b	-15.8 vs -9.9	0.03b
Böhm et al[12]	2015	None	998	-12	< 0.00001a	-6.6	< 0.00001a

^aP-value for within group change;

^bP-value for between group change. BP: Blood pressure; RDN: Renal sympathetic denervation; NA: Not available.