Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4

Figure 2 Changes in cytokine and matrix metalloproteinase mRNA expression in human cardiac myofibroblasts following incubation with Tenascin C. Effect of Tenascin C (TNC) (0.1 μmol/L, 24 h) on MMP1, MMP2, MMP3, MMP9, MMP10, MT1-MMP, IL-1β and IL-6 mRNA expression was assessed in human cardiac myofibroblasts (n = 4-6 donors). A significant increase in the expression of MMP3 and IL-6 was observed. Data are expressed as mean ± SEM. ^bP < 0.01 vs vehicle (student’s t-test). MMP: Matrix metalloproteinase; IL: Interleukin.