Micromanaging cardiac regeneration: Targeted delivery of microRNAs for cardiac repair and regeneration

Figure 2 The complex web of transcription factors in cardiac specification and their regulation by microRNAs. A: Crosstalk between transcription factors involved in the formation of the first and second heart field (light grey box). MESP1, GATA4, Mef2c, HAND2 and Nkx2.5 are central transcription factors in the first and second heart field (yellow). TBX5 is only expressed in the first heart field (green). ISL1 and TBX1 are expressed in the second heart field (blue); B: MicroRNA-mediated regulation of cardiac transcription factors during cardiomyocyte differentiation (dark grey box).