Novel epigenetic-based therapies useful in cardiovascular medicine

Table 1 Interventional and randomized ongoing clinical trials on the use of hydralazine and procainamide in cardiovascular diseases

No.	Status	Condition	No. of enrolled patients	Intervention
NCT00684489	Completed	Hypertension	52	Hydralazine and other drugs
NCT02305095	Not open for participant recruitment	Heart failure	500 (estimated enrollment)	Hydralazine in combination with isosorbide dinitrate
NCT00661895	Completed	Hypertension	99	Hydralazine and other drugs
NCT00599235	Completed	Hypertension	30	Hydralazine, sildenafil, and placebo
NCT00223717	Recruiting participants	Hypertension	160 (estimated enrollment)	Hydralazine and other drugs
NCT01255475	Completed	Heart failure, cardiac failure, and congestive heart failure	21	Hydralazine/amlodipine and placebo
NCT01516346	Recruiting participants	Heart failure and congestive heart failure	54 (estimated enrollment)	Hydralazine, isosorbide dinitrate, and placebo
NCT01822808	Recruiting participants	Acute heart failure and left ventricular dysfunction	500 (estimated enrollment)	Hydralazine, isosorbide dinitrate, and placebo
NCT00000499	Completed	Cardiovascular diseases, heart diseases, hypertension, and vascular diseases	Not provided	Hydralazine, reserpine, chlorthalidone, and metoprolol
NCT02050529	Recruiting participants	Hypertension, Pregnancy induced	180 (estimated enrollment)	Hydralazine, labetalol
NCT01538875	Completed	Hypertension, Pregnancy induced	261	Hydralazine, labetalol
NCT00383799	Unknown	Ventricular tachycardia	302 (estimated enrollment)	Procainamide, amiodarone
NCT00000464	Completed	Arrhythmia, Cardiovascular diseases	115	Procainamide, quinidine, disopyramide, and other drugs
NCT00702117	Completed	Atrial fibrillation, tachycardia	123	Procainamide, ajmaline, flecainide
NCT00589303	Terminated	Atrial fibrillation, heart failure	27	Rhythm control drugs: Procainamide and other drugs
NCT00000556	Completed	Arrhythmia, atrial fibrillation, cardiovascular diseases	4060	Procainamide and other drugs
NCT01205529	Recruiting	Atrial fibrillation	750 (estimated enrollment)	Procainamide