Micromanaging cardiac regeneration: Targeted delivery of microRNAs for cardiac repair and regeneration

doi:10.4330/wjc.v8.i2.163

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Feb 26, 2016; 8(2): 163-179
Published online Feb 26, 2016. doi: 10.4330/wjc.v8.i2.163

Table 1 MicroRNAs involved in cardiomyocytes differentiation

microRNA	Targets	Effect on cardiomyogenesis (mechanism)	Used in reprogramming	Ref.
Increased during cardiomyogenesis
1	Dll1 (Notch)	↑ CM Differentiation (↑ Nkx2.5 and Myogenin)	+	[102-104,106,109-111]
	Hes1 (Notch)	↑ CM Differentiation (↑ Nkx2.5 and GATA4)
	Hand2	↓ CM Proliferation
	HDAC4	↑ CM Differentiation (↑ Mef2c)
	Myocardin	↑ CM Maturation (↓ SMC phenotype)
30a-e	Snai2	↑ CM Differentiation (↓ mesenchymal genes)	-	[102,103,120]
	Smarcd2	↑ CM Differentiation (↓ mesenchymal genes)
	Tnrc6a	↑ CM Maturation (↓ miR-206: ↓ SMC Phenotype)
133a-b	Snai1	↑ CM Differentiation (↓ mesenchymal genes)	+	[102-105,113]
	SRF	↓ CM Proliferation
	Cyclin D2	↓ CM Proliferation
181a-d	?	↑ CM Proliferation	-	[103,175]
195	Cyclin D1	↓ CM Proliferation	-	[102,103,119,176]
195	HMGA	↓ CM Differentiation (↓ Nkx2.5)	-	[102,103,119,176]
208b	Myostatin	↑ CM Proliferation	+	[103,114,117,118]
	Sox6, Purβ	↑ CM Maturation (↑ beta-Myosin Heavy Chain)
	THRAP1	↑ CM Maturation (↑ beta-Myosin Heavy Chain)
499-5p	? (↑ Wnt)	↑ CM Differentiation (↑ Nkx2.5, Mef2c and GATA4)	+	[102,103,115]
Decreased during cardiomyogenesis
31	?	?	-	[103]
34c-3p	?	?	-	[103]
151-3p	ATP2a2	↓ CM Maturation (↓ beta-Myosin Heavy Chain)	-	[103,177]
221	?	?	-	[103]
222	?	?	-	[103]

ATP2a2: Sarcoplasmic reticulum Ca²⁺ ATPase 2; CM: Cardiomyocyte; Dll1: Delta-like 1; GATA4: GATA Binding Protein 4; Hand2: Heart and neural crest derivatives expressed 2; HDAC4: Histone deacetylase 4; Mef: Myocyte enhancer factor; miR: MicroRNA; Nkx2.5: NK2 homeobox 5; Purβ: Purine-rich element binding protein beta; Smarcd2: SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 2; SMC: Smooth muscle cell; Snai: Snail family zinc finger; Sox6: Sex determining region Y-box 6; SRF: Serum response factor; THRAP1: Thyroid hormone receptor associated protein 1; Tnrc6a: Trinucleotide repeat-containing gene 6A; Wnt: Wingless-type MMTV integration site family.

Citation: Kamps JA, Krenning G. Micromanaging cardiac regeneration: Targeted delivery of microRNAs for cardiac repair and regeneration. World J Cardiol 2016; 8(2): 163-179
URL: https://www.wjgnet.com/1949-8462/full/v8/i2/163.htm
DOI: https://dx.doi.org/10.4330/wjc.v8.i2.163