Percutaneous assist devices in acute myocardial infarction with cardiogenic shock: Review, meta-analysis

Table 2 Meta-analysis before and after sensitivity analysis

Comparison/subgroup	RR
	Before				After
	n	I2(%)	Estimate (95%CI)	P	n	I2(%)	Estimate (95%CI)	P
Inhospital mortality
IABP vs medical therapy
Observational studies	11	63	1.21 (1.08, 1.36)	0.0008	9	19	1.17 (1.09, 1.26)	< 0.0001
RCTs	2	0	0.97 (0.81, 1.18)	0.78	2	0	0.97 (0.81, 1.18)	0.78
Overall effect	13	62	1.18 (1.06, 1.32)	0.002	11	24	1.15 (1.07, 1.24)	0.0002
Test for subgroup differences1	χ2 = 3.83, df = 1 (P = 0.05), I2 = 73.9%				χ2 = 3.14, df = 1 (P = 0.08), I2 = 68.2%
ECMO plus IABP vs ECMO
Observational studies	6	12	0.78 (0.65, 0.94)	0.008	5	0	0.80 (0.68, 0.94)	0.006
Late mortality
IABP vs medical therapy
Observational studies	3	90	0.92 (0.51, 1.67)	0.78	2	60	1.16 (0.69, 1.95)	0.57
RCTs	3	32	1.16 (0.86, 1.58)	0.34	2	0	1.56 (0.97, 2.52)	0.07
Overall effect	6	85	1.08 (0.82, 1.41)	0.60	4	0	1.38 (1.30, 1.46)	< 0.00001
Test for subgroup differences1	χ2 = 0.48, df = 1 (P = 0.49), I2 = 0%				χ2 = 0.68, df = 1 (P = 0.41), I2 = 0%

¹Between observational studies and RCTs. IABP: Intra-aortic balloon pump; RCT: Randomized controlled trial; ECMO: Extracorporeal membrane oxygenation.