Insights into cardio-oncology: Polypharmacology of quinazoline-based &alpha;1-adrenoceptor antagonists

doi:10.4330/wjc.v7.i5.238

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May 26, 2015 (publication date) through Jul 6, 2024

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. May 26, 2015; 7(5): 238-242
Published online May 26, 2015. doi: 10.4330/wjc.v7.i5.238

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Figure 1 Structure and polypharmacology of quinazoline-based α1-adrenoceptor antagonists doxazosin, prazosin and terazosin in cardio-oncology. MDR: Multidrug resistance; EGFR: Epidermal growth factor receptor; FGFR-2: Fibroblast growth factor receptor-2; HIF-1α: Hypoxia-inducible factor 1α; mTOR: Mammalian target of rapamycin; PDK1: 3-phosphoinositide-dependent protein kinase 1; TGF: Transforming growth factor.

Citation: Patanè S. Insights into cardio-oncology: Polypharmacology of quinazoline-based α₁-adrenoceptor antagonists. World J Cardiol 2015; 7(5): 238-242
URL: https://www.wjgnet.com/1949-8462/full/v7/i5/238.htm
DOI: https://dx.doi.org/10.4330/wjc.v7.i5.238