Percutaneous pulmonary and tricuspid valve implantations: An update

Table 3 Haemodynamic outcome immediately post-percutaneous pulmonary valve implantation

	US Melody Valve Trial (n = 124)		London Melody experience(n = 151)		Munich/Berlin Melody experience (n = 102)		Philadelphia Melody experience(n = 104)		Early Edwards experience(n = 7)		Later Edwards experience(n = 36)
Parameter	Pre (median)	Post (median)	Pre (mean)	Post (mean)	Pre (mean)	Post (mean)	Pre (mean)	Post (mean)	Pre (mean)	Post (mean)	Pre (mean)	Post (mean)
RV systolic pressure, mmHg	65	41b	63	45b	NA	NA	72	47b	NA	NA	55	42b
Peak RV to PA gradient, mmHg	37	12b	37	17b	37	14	39	11b	NA	NA	27	12b
RV to systemic pressure, %	0.74	0.42b	0.69	0.4b	0.62	0.3b	NA	NA	0.78	0.3b	0.6	0.4b

Invasively measured pressures and gradients pre and post percutaneous pulmonary valve implantation within the largest trials (n > 100) of the MELODY^{TM[18,19,21,33]} and of SAPIEN^TM implants[28,30] in pulmonary position. In all studies, a profound improvement in RV to systemic pressure ratio in response to PPVI was seen (^bP≤ 0.001) (all parameters expressed by medians). RV: Right ventricular; PA: Pulmonary artery. NA: Not available.