Systematic Reviews
Copyright ©The Author(s) 2015.
World J Cardiol. Dec 26, 2015; 7(12): 948-960
Published online Dec 26, 2015. doi: 10.4330/wjc.v7.i12.948
Table 4 All studies that have used speckle-tracking echocardiography-based strain to predict adverse left ventricular remodelling
Ref.Age (yr)Sample size (male)Baseline ejection fraction (%)Timeframe baseline scanTimeframe follow-up scan(s)Definition of adverse remodellingOther parameters in multivariate modelResultsLimitations
Bochenek et al[70]59.6 ± 10.366 (53)49.7 ± 9.24-6 d post-infarct3 moEDV > 20%Diabetes22 patients remodelled; GLS can predict LV remodelling - OR = 1.19 (1.04-1.37), P < 0.05 - shown by multivariate analysis GLS > -12.5% can predict remodelling - AUC = 0.77 for ROC, sensitivity/specificity of 69%/79% respectivelyOnly longitudinal strain measured. Too many variables in multivariate analysis
Anterior MI
Leuk. Count
Time to reperfusion
WMSI
Max. Trop
ST-elevation max pre-PCI
Joyce et al[74]60 ± 121041 (792)47.0 ± 9.02 d post-PPCI3 and 6 moEDV ≥ 20%Male sexGLS > -15% can predict remodelling at 3 and 6 mo vs GLS < -15% (both P < 0.001): OR = 6.7 (2.8-11) for 3 mo; OR = 10 (6.7-14) for 6 moOnly longitudinal strain measured; Prognostic data divided categorically - i.e., GLS > -15% or < -15%; Excluded patients with re-infarction before follow-up and cardiogenic shock - could potentially have been used as another endpoint
LAD infarct
Max. Trop
Discharge heart rate
LA volume index
WMSI
Cong et al[71]59.9 ± 11.6127 (103)51.8 ± 5.11 d post-PPCI6-9 moESV ≥ 15%Anterior MI41 patients developed remodelling; GLS predicted remodelling - OR = 0.39 (0.26-0.57), P < 0.01; GLS = -10.85% had sensitivity/specificity of 89.7%/91.7% respectively by ROC to predict remodellingOnly longitudinal strain measured; Too many variables in the multivariate analysis
Time to reperfusion
∑ST before PPCI
∑ST post-PPCI
Raised CK-MB/Trops
Baseline ESV/EF
WMSI