Do neutrophil extracellular traps contribute to the heightened risk of thrombosis in inflammatory diseases?

Table 1 Neutrophil extracellular trap-associated molecules that may play a role in promoting thrombosis

NET component	Role in thrombosis
DNA backbone	Negatively charged surface capable of activating factor XII[80]
	Coassembly of TFPI and serine proteases at thrombus[86]
Histones	Platelet activation[83,84]
	Prevent activation of natural anticoagulant, protein C[85]
Elastase	Cleavage of TFPI[86]
	Cleavage of antithrombin[87]
	Strips proteoglycan layer of arterial media to expose VWF[88]
Cathepsin G	Cleavage of TFPI[86]
	Platelet activation[89,90]
Tissue factor	Platelet activation[91,104]
	Thrombin generation by extrinsic pathway of coagulation[91,104]

TFPI: Tissue factor pathway inhibitor; VWF: Von Willebrand factor; NET: Neutrophil extracellular trap.