Renal function assessment in atrial fibrillation: Usefulness of chronic kidney disease epidemiology collaboration vs re-expressed 4 variable modification of diet in renal disease

Table 3 Unadjusted and adjusted effect (HR) on outcomes of categorical estimated glomerular filtration rate determined by the re-expressed four variables Modification of Diet in Renal Disease and the new Chronic Kidney Disease Epidemiology Collaboration equations

		MDRD-4		CKD-EPI
n (%)		Unadjusted HR (95%CI)	Adjusted HR (95%CI)	Unadjusted HR (95%CI)	Adjusted HR (95%CI)
Composite endpoint, 98 (10.8)	≥ 60	1.00 (Reference)
	30-59	2.43 (1.592-3.703)	1.71 (1.11-2.78)	2.51 (1.642-3.827)	1.81 (1.1-2.8)
		P < 0.0001	P = 0.02	P < 0.0001	P = 0.02
	< 30	6.99 (3.585-13.649)	3.3 (1.6-6.9)	7.4 (3.871-14.125)	3.6 (1.8-7.4)
		P < 0.0001	P = 0.001	P < 0.0001	P < 0.0001
Major bleeding, 30 (3.3)	≥ 60	1.00 (Reference)
	30-59	1.53 (0.715-3.260)	1.012 (0.46-2.25)	1.87 (0.883-3.948)	1.22 (0.58-2.75)
		P = 0.30	P = 0.95	P = 0.1	P = 0.58
	< 30	3.56 (0.811-15.580)	1.03 (0.22-4.95)	3.65 (0.827-16.074)	1.1 (0.25-5.35)
		P = 0.09	P = 0.93	P = 0.08	P = 0.9
Thromboembolism, 18 (2)	≥ 60	1.00 (Reference)
	30-59	2.04 (0.734-5.649)	1.43 (0.49-4.15)	2.13 (0.767-5.917)	1.43 (0.50-4.25)
		P = 0.17	P = 0.15	P = 0.15	P = 0.50
	< 30	8.01 (1.664-38.555)	5.1 (1.04-25.4)	7.84 (1.625-37.825)	5 (1.0-24.9)
		P = 0.009	P = 0.045	P = 0.01	P = 0.04
All-cause mortality, 60 (6.6)	≥ 60	1.00 (Reference)
	30-59	3.34 (1.909-5.827)	2.64 (1.4-2.7)	3.14 (1.793-5.481)	2.44 (1.3-4.5)
		P < 0.0001	P = 0.002	P < 0.0001	P = 0.005
	< 30	10.64 (4.843-23.359)	4.9 (2.0-11.9)	10.89 (5.122-23.166)	5.2 (2.2-12.3)
		P < 0.0001	P < 0.0001	P < 0.0001	P < 0.0001

¹Adjusted for age, sex, previous stroke, basal hemoglobin, chronic obstructive pulmonary disease, diabetes mellitus, congestive heart failure or ejection fraction ≤ 40%, history of malignant disease and coronary artery disease;

²Adjusted for HAS-BLED risk score [Hypertension (uncontrolled: systolic > 160 mmHg)], Abnormal renal function, abnormal liver function, stroke, bleeding history or predisposition (anemia), labile international normalized ration (INR), elderly > 65 years, and drugs/alcohol concomitantly);

³Adjusted for CHA2DS2-VAScscore [Cardiac failure or dysfunction, Hypertension, Age ≥ 75 years (doubled), Diabetes, Stroke (doubled), Vascular disease, Age 65 to 74 years, and Sex category (female)];

⁴Adjusted for age, sex, diabetes mellitus, history of malignant disease, previous stroke, basal hemoglobin and congestive heart failure or ejection fraction ≤ 40%. CKD-EPI: Chronic Kidney Disease Epidemiology Collaboration; MDRD-4: 4-variable Modification of Diet in Renal Disease Study equation.