Renal function assessment in atrial fibrillation: Usefulness of chronic kidney disease epidemiology collaboration vs re-expressed 4 variable modification of diet in renal disease

Table 2 Unadjusted and adjusted effect (HR) on outcomes of continuous estimated glomerular filtration determined by the re-expressed Four variables Modification of Diet in Renal Disease and the new Chronic Kidney Disease Epidemiology Collaboration equations

	MDRD-4		CKD-EPI
n (%)	Unadjusted HR (95%CI)	Adjusted HR (95%CI)	Unadjusted HR (95%CI)	Adjusted HR (95%CI)
Composite endpoint, 98 (10.8)	0.97 (0.958-0.977)	0.981 (0.967-0.988)	0.96 (0.955-0.975)	0.971 (0.963-0.987)
P value	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Major bleeding, 30 (3.3)	0.97 (0.951-0.985)	0.982 (0.965-1.000)	0.97 (0.949-0.984)	0.982 (0.965-1.000)
P value	< 0.0001	0.07	< 0.0001	0.07
Thromboembolism, 18 (2)	0.98 (0.959-1.003)	0.983 (0.965-1.000)	0.97 (0.948-0.996)	0.983 (0.965-1.001)
P value	0.09	0.15	< 0.0001	0.22
All-cause mortality, 60 (6.6)	0.96 (0.948-0.973)	0.984 (0.965-0.995)	0.96 (0.947-0.971)	0.984 (0.965-0.995)
P value	< 0.0001	< 0.0001	0.02	0.001

¹Adjusted for age, sex, previous stroke, basal hemoglobin, chronic obstructive pulmonary disease, diabetes mellitus, congestive heart failure or left ventricular ejection fraction ≤ 40%, history of malignant disease and coronary artery disease;

²Adjusted for HAS-BLED risk score [Hypertension (uncontrolled: systolic >160 mmHg)], abnormal renal function, abnormal liver function, stroke, bleeding history or predisposition (anemia), labile international normalized ration (INR), elderly > 65 years, and Drugs/alcohol concomitantly);

³Adjusted for CHA2DS2-VAScscore [Cardiac failure or dysfunction, Hypertension, Age ≥ 75 years (doubled), Diabetes, Stroke (doubled), Vascular disease, Age 65 to 74 years, and Sex category (female)];

⁴Adjusted for age, sex, diabetes mellitus, history of malignant disease, previous stroke, basal hemoglobin and congestive heart failure or ejection fraction ≤ 40%. CKD-EPI: Chronic Kidney Disease Epidemiology Collaboration; MDRD-4: 4-variable Modification of Diet in Renal Disease Study equation.