End-organ protection in hypertension by the novel and selective Rho-kinase inhibitor, SAR407899

Figure 2 SAR407899 efficiently lowers blood pressure, proteinuria and mortality in hypertensive rats. Invasive measurement of blood pressure in deoxycorticosterone acetate (DOCA) (A) and in Nω-Nitro-L-arginine methyl ester hydrochloride (LNAME) (B) rats. At the given dose, SAR407899 showed superior blood pressure lowering effect in comparison to ramipril and amlodipine in both animal models; C and D: Assessment of kidney function in DOCA and LNAME rats. SAR407899 showed significant protective effects on the kidneys in both models, whereas ramipril reduced albuminuria only in the LNAME model. Amlodipine had no therapeutic effect on kidney in either model.