End-organ protection in hypertension by the novel and selective Rho-kinase inhibitor, SAR407899

Figure 1 Effect of SAR407899 on body weight in deoxycorticosterone acetate and Nω-Nitro-L-arginine methyl ester hydrochloride hypertensive animals. A and B: Body weight of deoxycorticosterone acetate (DOCA) rats. A significant decrease in body weight was observed after 28 d; A: Effect of SAR407899 at 3 mg/kg and 10 mg/kg on body weight. Both doses protected DOCA rats against body weight loss; B: Effect of ramipril at 1 mg/kg and amlodipine at 3 mg/kg on body weight. Only amlodipine showed protective effects on body weight loss; C and D: Body weight of Nω-Nitro-L-arginine methyl ester hydrochloride (LNAME) rats. A significant decrease in body weight was observed after 22 d. C: SAR407899 at 10 mg/kg significantly protected LNAME rats from body weight loss; D: Effect of ramipril at 1 mg/kg and amlodipine at 3 mg/kg on body weight. Only ramipril showed significant protective effects on body weight loss.