Helicobacter pylori: Does it add to risk of coronary artery disease

Table 2 Effect of Helicobacter pylori eradication on coronary artery disease

Ref.	Population	Intervention	Results
Kowalski et al[47,48]	40 patient with single vessel CAD and H. pylori infection	All underwent PTCA and 20 each received eradication or placebo	Attenuated reduction mean coronary artery lumen at 6 mo in those undergoing eradication
Lu et al[49]	H. pylori positive individuals	Testing of coronary risk factors before and after H. pylori eradication	No change in sugar, lipid and fibrinolytic parameters with eradication
Pellicano et al[50]	H. pylori positive individuals	Testing of coronary risk factors before and after H. pylori eradication	Improvement in HDL-C, reduction in CRP and fibrinogen levels. Elevation in BMI and diastolic blood pressure
Gen et al[51]	H. pylori positive individuals	Testing for insulin resistance, lipid profile and CRP before and after eradication	Improvement in insulin resistance, lipid abnormalities and CRP levels
Kanbay et al[52]	H. pylori positive individuals	Testing for lipid profile and CRP before and after eradication	Increase in HDL and reduction in CRP with successful eradication

CAD: Coronary artery disease; CRP: C-reactive protein; HDL: High density lipoprotein; PTCA: Percutaneous transluminal coronary angioplasty; H. pylori: Helicobacter pylori.