Drug-eluting stents and acute myocardial infarction: A lethal combination or friends?

Table 1 Randomized controlled trials of first-generation drug eluting stents in stent thrombosis elevated myocardial infarction

Study, author (Ref.)	Year	Primary endpoint	Design	Randomized ratio	Maximal length of follow-up	Stent comparators (n)	Results of the primary endpoint
Pasceri et al[19]	2003	Death, MI, recurrent ischemia at 1 yr	Single center	1:1	1 yr	BMS/SES 65 (33/32)	No significant differences between stents
TYPHOON[4]	2006	TVF at 1 yr	Multicenter, superiority	1:1	4 yr	BMS/SES 712 (355/357)	SES superior to BMS
STRATEGY[20]	2007	Death, MI, stroke, binary restenosis at 8 mo	2-center, superiority	1:1	2 yr	BMS/SES 175 (87/88)	SES superior to BMS
SESAMI[21,22]	2007	Binary restenosis at 1 yr	Single-center, superiority	1:1	5 yr	BMS/SES 320 (160/160)	SES superior to BMS
Díaz de la Llera et al[23]	2007	Death, MI, TLR at 1 yr	Single center, superiority	1:1	1 yr	BMS/SES 114 (54/60)	SES superior to BMS
MISSION[24]	2008	In-segment late luminal loss at 9 mo	Single center, noninferiority	1:1	5 yr	BMS/SES 310 (152/158)	SES superior to BMS
MULTISTRATEGY[25]	2008	Death, MI, clinically driven TVR at 8 mo	Multicenter, superiority	1:1	3 yr	BMS/SES 744 (372/372)	SES superior to BMS
HAAMU-STENT[26]	2006	Death, MI, late lumen loss, TVR at 1 yr	Single center, superiority	1:1	1 yr	BMS/PES 164 (82/82)	PES superior to BMS
SELECTION[27]	2007	Neointimal proliferation by IVUS at 7 mo	Single-center, superiority	1:1	7 mo	BMS/PES 76 (39/37)	PES superior to BMS
PASSION[28]	2008	Cardiac death, MI, TLR at 2 yr	2-center, superiority	1:1	5 yr	BMS/PES 619 (310/309)	Superiority not demonstrated
HORIZONS-AMI[5,29]	2009	TLR Death, MI, stroke, or ST at 1 yr	Multicenter, superiority (TLR) Noninferiority (Death, MI, stroke, ST)	3:1	3 yr	BMS/PES 3006 (2257/749)	PES superior for TLR and noninferior for clinical endpoints
GRACIA-3[30]	2010	In-segment binary restenosis, myocardial flow at 1 yr	Multicenter, noninferiority	1:1	1 yr	BMS/PES 419 (210/209)	BMS noninferior to PES
PROSIT[31]	2008	Death, MI, TVR, ST at 1 yr	Multicenter, superiority	1:1	3 yr	PES/SES 308 (154/154)	Superiority not demonstrated
Juwana et al[32]	2009	Late lumen loss at 9 mo	Single center, superiority	1:1	1 yr	PES/SES 397 (196/201)	SES superior to PES
PASEO[33]	2009	TLR at 12 mo	Single-center, superiority	1:1:1	4 yr	BMS/PES/SES 270 (90/90/90)	PES and SES superior to BMS

MI: Myocardial infarction; TLR: Target lesion revascularization; ST: Stent thrombosis; PES: Paclitaxel-eluting stents; SES: Sirolimus-eluting stents; BMS: Bare metal stent stents; TVR: Target vessel revascularization; IVUS: Intravascular ultrasound.