Neuregulin-1/erbB activities with focus on the susceptibility of the heart to anthracyclines

Figure 4 Functional interaction of molecules placed at the T-tubules. The ErbB2 and ErbB4 proteins are localized to the T-tubules. This compartment of the sarcolemma provides specific sites for functional interactions with molecules at the sarcoplasmic reticulum and at the myofibril Z-band. Molecular interactions at the T-tubules and at the intercalated discs provide the electric-contractile coupling of the myocardium. Scheme of the sarcomeric units of thin and thick filaments are anchored by titin and actin at the Z-band viaα-actinin scaffold protein complex. Muscle LIM domain protein (MLP), telethonin (T-cap) and PDZ and LIM domain protein (ZASP). PDZ: Postsynaptic density 95, disc large and zonula occludens-1; ADAM: A desintegrin and metallopeptidase; SERCA: Sarcoplasmic reticulum calcium ATPase; Plb: Phospholamban; RyR: Ryanodine receptor; SR: Sarcoplasmic reticulum.