Neuregulin-1/erbB activities with focus on the susceptibility of the heart to anthracyclines

doi:10.4330/wjc.v6.i7.653

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Jul 26, 2014; 6(7): 653-662
Published online Jul 26, 2014. doi: 10.4330/wjc.v6.i7.653

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Figure 1 Endothelium-Cardiac muscle interactions through paracrine neuregulin-1 signaling. Secreted neuregulin-1 from endothelial cells binds to erbB4 inducing auto- and trans-phosphorylation of ErbB2/ErbB4 heterodimers, expressed in cardiomyocytes. NRG-1: Neuregulin-1; PDZ: Postsynaptic density 95, disc large and zona occludens-1 homologous protein domain; ADAM: A desintegrin and metallopeptidase; P: Phosphorylated tyrosine.

Citation: Vasti C, Hertig CM. Neuregulin-1/erbB activities with focus on the susceptibility of the heart to anthracyclines. World J Cardiol 2014; 6(7): 653-662
URL: https://www.wjgnet.com/1949-8462/full/v6/i7/653.htm
DOI: https://dx.doi.org/10.4330/wjc.v6.i7.653