Mechanisms underlying the impaired contractility of diabetic cardiomyopathy

Figure 2 Summary of intracellular Ca²⁺ and isometric stress parameters. Data were recorded from left ventricular trabeculae at 37 °C, 5 Hz stimulation frequency, and 1.5 mmoL [Ca²⁺]o. Data are mean ± SE 8 wk post injection for control (n = 7) and diabetic (n = 8). A: Shows resting and peak [Ca²⁺]i. The Ca²⁺ transients were prolonged in diabetic trabecuae; B: Shows the time to reach peak [Ca²⁺]i, and the time constant of the Ca²⁺ transient decay; C: Shows no difference in resting stress, but peak stress was reduced in diabetic trabeculae; D: Shows the time to 50% relaxation of stress was prolonged in diabetic, as was the time from the peak of the Ca²⁺ transient to the peak of the twitch. ^aP < 0.05, diabetic vs control.