Review
Copyright ©2014 Baishideng Publishing Group Inc.
World J Cardiol. Jul 26, 2014; 6(7): 638-652
Published online Jul 26, 2014. doi: 10.4330/wjc.v6.i7.638
Table 1 Effect of calpain inhibitor A-705239 on impairment of mitochondrial function following myocardial ischemia and reperfusion[180]
nState 3 respiration (nmol O2/min per milligram)State 4 respiration (nmol O2/min per milligram)RCI (state3 rate): (state 4 rate)Leak respiration(nmol O2/min per milligram)Stimulation by cytochrome c %
Control
Before ischemia46.4 ± 1.10.5 ± 0.112.5 ± 2.70.15 ± 0.076.0 ± 10.0
Ischemia 45 min83.5 ± 1.4ac0.9 ± 0.3a4.4 ± 2.5a0.32 ± 0.14a10.0 ± 6.0
Reperfusion 60 min42.6 ± 1.3ac0.9 ± 0.3a3.2 ± 2.1a0.43 ± 0.2928.0 ± 16.0
A-705239 treated hearts
Before ischemia46.8 ± 1.30.6 ± 0.112.4 ± 1.10.12 ± 0.0616.0 ± 9.0
Ischemia 45 min95.0 ± 0.8ac0.6 ± 0.28.2 ± 2.3ac0.20 ± 0.14a15.0 ± 13.0
Reperfusion 60 min54.2 ± 1.2ac0.7 ± 0.26.4 ± 2.7a0.26 ± 0.24