Stem cell mechanisms during left ventricular remodeling post-myocardial infarction: Repair and regeneration

Table 3 Recently published clinical trials of stem cell therapies for acute treatment post-myocardial infarction

	Clinical trial	Outcome	Ref.
2010	Influence of bone marrow stem cells on left ventricular perfusion and ejection fraction in patients with acute myocardial infarction of anterior wall: Randomized clinical trial	Slight improvement of myocardial profusion	[109]
2011	HEBE trial	No significant improvement on regional or global function	[110]
2011	Late TIME trial	No improvement on global or regional function at 6 mo	[111]
2012	Stem cell treatment for acute myocardial infarction	Reduced LVESV, LVEDV, and infarct size	[109]
2012	CADUCEUS trial	Reduced scar mass, increased myocardium viability, regional contractility and wall thickness	[112]
2012	Enhanced mobilization of the bone marrow-derived circulating progenitor cells by intracoronary freshly isolated bone marrow cells transplantation in patients with acute myocardial infarction	Feasibility, safety, and improvement on recovery of LV contractility	[113]
2013	The C-CURE trial	Feasibility, safety and improved LV ejection fraction	[114]

LV: Left ventricular; LVESV: Left ventricular end systolic volume; LVEDV: Left ventricular end diastolic volumes; CADUCEUS: CArdiosphere-derived autologous stem cells to reverse ventricular dysfunction; C-Cure: Cardiopoietic stem cell therapy in heart failure.