G-protein-coupled estrogen receptor as a new therapeutic target for treating coronary artery disease

Table 2 Evidence for possible therapeutic effects of G-protein-coupled estrogen receptor agonists and selective estrogen receptor modulators

	Species	Drug
Coronary artery relaxation
Endothelium-dependent, in vitro	Porcine	G-1[36]
	Rabbit	Raloxifen[54]
		Tamoxifen[73,74]
Endothelium-independent, in vitro	Porcine	G-1[46]
		Raloxifen[37]
Reduced cardiac ischemic injury/infarct	Rat	G-1[75,76]
Reduced cerebral ischemic injury/infarct	Mice	G-1[77]
Middle cerebral artery relaxation, in vitro	Rat	G-1[78]
Systemic artery relaxation, in vitro	Mice	G-1[40]
		G-1[49]
		G-1[50]
		G-1[79]
	Rat	G-1[51]
		G-1[52]
	Human	G-1[50]
Reduced systemic blood pressure, infusion	Rats	G-1[49]
		G-1[50]
Inhibit VSM cell proliferation	Porcine	G-1[47]
	Human	G-1[50]
Inhibit endothelial cell proliferation	Mice	G-1[70]
Prevents calcium-induced increases in plasma cholesterol	Rats	G-1[80]

VSM: Vascular smooth muscle.