Elevated blood pressure: Our family’s fault? The genetics of essential hypertension

Table 4 MiRNA targets associated with essential hypertension

Ref.	Subjects	Results	miRNA targets
Xu et al[76]	Human plasma	hcmv-miR-UL112; miR-605; miR-623; let-7e;miR-516b; miR-600; kshv-miR-K12-6-3p; miR-602; miR-1252 miR-296-5p; miR-133b; miR-30 d; miR-625*; miR- 1236; miR-518b; miR-1227; miR-664; miR-615-5p; miR-18b*; miR- 1249; miR-324-3p; ebv-miRBART17-3p; miR-634; ebvmiR-miRBART19-5p; miR-486-5p; kshvmiR-K12-10a; kshv-miR-K12-10b	INF-1 is direct target of hmcv-miR-UL112 Indicates link between CMV infection and EH
Batkai et al[77]	Human	Endothelial miRNA miR-126 miR-217 miR-122 miR-21 miR-24 miR-27b, -130a, -210, -378, -17–92, let-7f miR-15, -16, -20a, -20b, -24, -221, -222 Renal miRNA miR-29b miR-200a, miR-200b, miR-141, miR-429, miR-205, miR-192 miRNA targeting RAAS miR-155 miR-526b and -578 miR-34a, and -34c miR-765 miR-383 miR-9 miR-124 and miR-135a miRNA targeting smooth muscle cells miR-143 and miR-145 miR-21 miR-21, -26b, -98, and -1826 miR-221 and -222 miRNA in other etiologic factors miR-296-5p, let-7e, hcmv-miR-UL112 hcmv-miR-UL1 miR-637	SPRED-1; PIK3 regulatory subunit-2; VCAM-1; CXCL12; RhoB SirT1 SLC7A1 Nitric oxide pathway Hypoxia-induced mechanism Pro-angiogenic Anti-angiogenic Fibrotic pathway; collagen genes; Mmp2; Itgb1 Biomarkers of nephrosclerosis AGTR1AVPR1ABDKRB2TBXA2RNR3C2NFATc3NR3C2 Actin stress fibers; ACE; KLF5; myocardin; MRTF-B; calmodulin kinase II-δ PTEN; Bcl-2; cGMP signaling Nitric oxide and ANP pathway p27(Kip1), p57(Kip2) and/or c-kit Association with hypertension IRF-1 ATP6V0A1, chromaffin granule function
Fung et al[78]	Human	miR-155	Suppress expression of AGTR1

Table 4 demonstrates how miRNAs affect different aspects of blood pressure regulation. Also, there appears to be a link between cytomegalovirus (CMV) infections and essential hypertension; miRNA has been identified as a possible mediator of this connection. The asterisk identified for some miRNAs[78] are not defined in the original article, but are assumed to be a part of the proper notation for that miRNA. EH: Essential hypertension.