Elevated blood pressure: Our family’s fault? The genetics of essential hypertension

Table 1 Genetic associations with essential hypertension according to cohort

Cohort	Genes
Framingham offspring cohort	CCL20-WDR69, CDH13, TGFBR2, STK39
Amish cohort	STK39
AGEN	NPR3, CYP17A1, FGF5, MTHFR, NPPA, NPPB, ATP2B1, CSK, ZNF652
BP-extremes	UMOD
BRIGHT	BCAT1
CARe	c21orf91, GPR98 and ARRDC3
CBPgen	CYP17A1, CACNB2, PLEKHA7, SH2B3, TBX3, TBX 4, TBX5, ULK4
CHARGE	CPLX3, PLEKHA7, TBX3, UMOD, CYP17A1, CSK-ULK3, CYP1A2, NT5C2, CYP171A, PLCD3, SH2B3-ATXN2, CACNB2, SH2B3, TBX3, TBX4, TBX5, ULK4, c10orf107, BLK-GATA4, CASZ1, FGF5, MTHFR, NPPA, NPPB, ATP2B1, CSK
FHS	ANKMY, FOXD3
GBPgen	UMOD, CSK-ULK3, CYP1A2, NT5C2, CYP171A, PLCD3, SH2B3-ATXN2,ATXN2, c10orf107, GNAS-EDN3, MECOM (MDS1 locus), FGF5, MTHFR, NPPA, NPPB, ATP2B1, CSK, ZNF652
GENE-centric	SOX6, AGT, LSP1-TNNT3, MTHFR, NPPA, NPPB, ATP2B1, HFE
Health2	ATP2B1
HUFS	IPO7, MYLIP, PMS1, SLC24A4, YWHAZ, CACANA1H
Hypergenes	NOS3
ICBP	ADAMTS-8, ADM, BAT2-BAT5, CHIC2-PDGFRA1, EBF1, FES, FIGN, FLJ32810-TMEM133, GOSR2, GUCY1A3-GUCY1B3, JAG1, MOV10, NOV, NPR3-c5orf23, PIK3CG, PLCE1, SLC39A8, SLC4A7, NPR3, CYP17A1, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, GNAS-EDN3, MECOM (MDS1 locus), FGF5, MTHFR, NPPA, NPPB, ATP2B1, CSK, ZNF652, HFE
KARE	ATP2B1
KORA S3	CCNG1
Suita study	CCBE1
WGHS	BLK-GATA4, CASZ1
Study reference not mentioned in article	ADD1, ADD2, ADRB1, ADRB2, APOB, CACNA1A, CACNA1C, CLCNKB, CYBA, CYP11B2, CYP2C8, EDN1, EDNRA, GNB3, SCNN1A, SCNN1B, SCNN1G, SGK1, KCNJ1, ACE, ADRB2, AGT, APLNR, BDKRB2, CAPN13, CYP11B2, CYP19A, GNB3, MMP3

Bolded genes are ones are found in multiple cohorts. The genes are identified and listed according to their respective cohorts, with a separate category to identify genes without specific references in any of the articles reviewed. Specific locations for the genes are provided where possible. Novel genes are identified, as are genes associated with physical properties.