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Copyright ©2014 Baishideng Publishing Group Inc.
World J Cardiol. May 26, 2014; 6(5): 283-294
Published online May 26, 2014. doi: 10.4330/wjc.v6.i5.283
Table 2 Summary of the main mechanisms underlying ethanol-induced hypertension
Ref.Mechanism
[17,18]Increase in sympathetic nervous system activity
[20]Stimulation of the renin-angiotensin-aldosterone system
Myogenic mechanism:
[31,32,36-42]Enhanced vascular reactivity to vasoconstrictor agents
[33,41,44-46]Impairment of the vascular relaxation
Oxidative stress:
[70-77]Increase in reactive oxygen species generation
[81,82,85-87]Reduction of antioxidant systems
[28,44,52,95-102]Decrease of nitric oxide bioavailability and endothelial dysfunction