Duration of dual antiplatelet treatment in the era of next generation drug-eluting stents

Table 2 Clinical outcomes of EXCELLENT trial n (%)

Clinical outcomes	6-mo DAPT	12-mo DAPT	HR1	P
	(n = 722)	(n = 721)	(95%CI)
Target vessel failure2	34 (4.8)	30 (4.3)	1.14 (0.70-1.86)	0.60
Total death	4 (0.6)	7 (1.0)	0.57 (0.17-1.95)	0.37
Cardiac death	2 (0.3)	3 (0.4)	0.67 (0.11-3.99)	0.66
Myocardial infarction	13 (1.8)	7 (1.0)	1.86 (0.74-4.67)	0.19
Death/myocardial infarction	17 (2.4)	14 (1.9)	1.21 (0.60-2.47)	0.58
Target vessel myocardial infarction	12 (1.7)	6 (0.8)	2.00 (0.75-5.34)	0.16
Cerebrovascular accident	3 (0.4)	5 (0.7)	0.60 (0.14-2.51)	0.48
Target lesion revascularization	17 (2.4)	18 (2.6)	0.94 (0.49-1.83)	0.86
Target vessel revascularization	22 (3.1)	22 (3.2)	1.00 (0.56-1.81)	0.99
Any revascularization	43 (6.2)	43 (6.2)	1.00 (0.66-1.53)	0.99
Stent thrombosis	6 (0.9)	1 (0.1)	6.02 (0.72-49.96)	0.10
Any bleeding	4 (0.6)	10 (1.4)	0.40 (0.13-1.27)	0.12
TIMI major bleeding	2 (0.3)	4 (0.6)	0.50 (0.09-2.73)	0.42
MACCE3	56 (8.0)	60 (8.5)	0.94 (0.65-1.35)	0.72
Safety end point4	24 (3.3)	21 (3.0)	1.15 (0.64-2.06)	0.64

The percentages shown are Kaplan-Meier estimates from the intention-to-treat analysis.

¹HRs are for the 6 mo vs 12 mo DAPT group;

²Target vessel failure was a composite of cardiac death, myocardial infarction or target vessel revascularization;

³MACCE was a composite of death, myocardial infarction, stroke or any revascularization;

⁴Safety end point was a composite of death, myocardial infarction, stroke, stent thrombosis or TIMI major bleeding. (Modified from Ref. [12]). DAPT: Dual antiplatelet therapy; TIMI: Thrombolysis in myocardial infarction; MACCE: Major cardiocerebral event.