Complicated Whipple’s disease and endocarditis following tumor necrosis factor inhibitors

Table 5 Lack of reliability of standard diagnostic procedures in patient group I: Summary of all diagnostic tests n (%)

	PAS-stain	PCR-test
	False negative	False negative
Before TNFI therapy	9/9 (100)	1/1 (100)
After TNFI therapy	5/13 (38.4)	0/10 (0)
Total	14/22 (63.6)b	1/11 (9.1)
	True positive	True positive
Before TNFI therapy	0/9 (0)	0/1 (0)
After TNFI therapy	8/13 (61.6)	10/10 (100)
Total	8/22 (36.4)b	10/11 (90.9)

^bP < 0.01 vs periodic acid-Schiff staining (PAS)- and polymerase chain reaction (PCR)-tests. TFNI: Tumor necrosis factor alpha inhibitor.