Blood cellular mutant LXR-α protein stability governs initiation of coronary heart disease

Figure 1 Gene expression analysis of various genes with respect to gensini score. A: Mean values of liver X receptor-α (LXR-α) protein levels in peripheral blood mononuclear cells (PBMCs) isolated from coronary heart disease (CHD) subjects and healthy controls with respect to increasing gensini score (reflecting the severity of coronary occlusion). Each bar represents mean ± SD for 10 different individuals in each group. The means were compared with one way ANOVA and ^aP < 0.05 vs control group; B: Statistical correlation between translational expression of mutant LXR-α and gensini score within PBMCs. Values of r show Spearman rank correlation coefficient and P < 0.01 was considered statistically significant; C, D: Mean values of [breast and ovarian cancer susceptibility1 (BRCA1)-associated RING domain 1] (BARD1) and BRCA1 (C) and interleukin (IL)-8, interferon (IFN)-γ, IL-6, and ATP-binding cassette A1 (ABCA1) (D) mRNA expression (change in ΔCt values) in PBMCs derived from CHD patients and healthy controls with respect to increasing Gensini Score. Each bar represents mean ± SD for 10 different individuals in each group. The means were compared with one way ANOVA and ^aP < 0.05 vs control group.