Early detection of cardiac involvement in thalassemia: From bench to bedside perspective

Table 1 Summary of the controversial correlation between cardiac magnetic resonance T2* and serum ferritin in thalassemia major

Population/size	Type of study	Findings	Correlation	Ref.
TM/652 patients	Prospective	Significant correlation between cardiac T2* and ferritin	/	Kirk et al[56]
		(r2 = 0.003, P = 0.04)
TM/776 patients	Retrospective	Significant relationship between cardiac R2* and ferritin	/	Marsella et al[59]
		(r = -0.359, P < 0.0001)
TM/167 patients	Prospective	Myocardial T2* was correlated with serum ferritin	/	Tanner et al[60]
		(r = -0.34, P < 0.001)
TM/19 patients, SCD/17 patients	Cross sectional	Cardiac 1/T2* was correlated with ferritin level	/	Wood et al[61]
		(r2 = 0.33, P = 0.01)
TM/106 patients	Prospective	No significant correlation between heart T2* and serum ferritin	×	Anderson et al[16]
TM/60 patients	Prospective	Serum ferritin did not correlate with cardiac iron values	×	Merchant et al[57]
TM/20 patients	Prospective	No correlation between serum ferritin and cardiac T2*	×	Kolnagou et al[58]
TM/47 patients	Retrospective	Cardiac T2* was not associated with the serum ferritin	×	Bayraktaroğlu et al[22]

TM: Thalassemia major; SCD: Sickle cell disease.