Implications of discoveries from genome-wide association studies in current cardiovascular practice

Figure 4 Significant genome-wide association study findings in low-density lipoprotein cholesterol. CELSR2: Cadherin EGF LAG seven-pass G-type receptor 2; PSRC1: Proline/serine-rich coiled-coil 1; SORT1: Sortilin 1; PCSK9: Proprotein convertase subtilisin/kexin type 9; APOB: Apolipoprotein B; ABCG: ATP-binding cassette sub-family G; GCKR: Glucokinase (hexokinase 4) regulator; TIMD4: T-cell immunoglobulin and mucin domain containing 4; HAVCR1: Hepatitis A virus cellular receptor 1; HMGCR: 3-hydroxy-3-methylglutaryl-CoA reductase; MYLIP: Myosin regulatory light chain interacting protein; HFE: Human hemochromatosis; LPA: Lipoprotein, Lp(a); DNAH11: Dynein axonemal heavy chain 11; KLF14: Kruppel-like factor 14; TRIB1: Tribbles homolog 1; PLEC1: Plectin; ABO: ABO blood group (transferase A, α 1-3-N-acetylgalactosaminyltransferase, transferase B, α 1-3-galactosyltransferase); FADS: Fatty acid desaturase; APOA1: Apolipoprotien A1; ST3GAL4: ST3 β-galactoside α-2;3-sialyltransferase 4; CCDC92: Coiled-coil domain containing 92; DNAH10: Dynein axonemal heavy chain 10; ZNF664: Zinc finger protein 664; HNF1A: HNF1 homeobox A; NYNRIN: NYN domain and retroviral integrase containing; CETP: Cholesteryl ester transfer protein plasma; OSBPL7: Oxysterol binding protein-like 7; NCAN: Nucleoporin 214kDa; CILP2: Cartilage intermediate layer protein 2; PBX4: Pre-B-cell leukemia homeobox 4; LDLR: Low-density lipoprotein receptor; TOMM40: Translocase of outer mitochondrial membrane 40 homolog; APOE: Apolipoprotien E; APOC2: Apolipoprotein C-II; APOE: Apolipoprotien E; BCAM: Basal cell adhesion molecule; BCL3: B-cell CLL/lymphoma 3; PVRL2: Poliovirus receptor-related 2 (herpesvirus entry mediator B); PLPT: Proteolipid protein; MAFB: V-maf musculoaponeurotic fibrosarcoma oncogene homolog B; TOP1: Topoisomerase (DNA) 1.