Implications of discoveries from genome-wide association studies in current cardiovascular practice

Figure 2 Significant genome-wide association study findings in total cholesterol. TMEM57: Transmembrane protein 57; DOCK7: Dedicator of cytokinesis 7; CELSR2: Cadherin, EGF LAG seven-pass G-type receptor 2; LDLRAP1: Low-density lipoprotein receptor adaptor protein 1; EVI5: Ecotropic viral integration site 5; IRF2BP2: Interferon regulatory factor 2 binding protein 2; APOB: Apolipoprotein B; ABCG5: ATP-binding cassette sub-family G member 5; RAB3GAP1: RAB3 GTPase activating protein subunit 1 (catalytic); RAF1: V-raf-1 murine leukemia viral oncogene homolog 1; HMGCR: 3-hydroxy-3-methylglutaryl-CoA reductase; TIMD4: T-cell immunoglobulin and mucin domain containing 4; HLA: Human leukocyte antigen (HLA) complex; C6orf106: Chromosome 6 open reading frame 106; FRK: Fyn-related kinase; DNAH11: Dynein, axonemal, heavy chain 11; NPC1L1: NPC1 (Niemann-Pick disease; type C1, gene)-like 1; TRIB1: Tribbles Homolog-1 (Trib1); CYP7A1: Cytochrome P450, family 7, subfamily A, polypeptide 1; TRPS1: Trichorhinophalangeal syndrome 1; GPAM: Glycerol-3-phosphate acyltransferase, mitochondrial; FADS: Fatty acid desaturase; SPTY2D1: Suppressor of Ty, domain containing 1 (S. cerevisiae); UBASH3B: Ubiquitin associated and SH3 domain containing B; BRAP: BRCA1 associated protein; HNF1A: Hepatocyte nuclear factor-1 α; HPR: Haptoglobin-related protein; LDLR: Low-density lipoprotein receptor; NCAN: Neurocan; TOMM40: Translocase of outer mitochondrial membrane 40 homolog; CILP2: Cartilage intermediate layer protein 2; ERGIC3: Endoplasmic reticulum-Golgi intermediate compartment protein 3; MAFB: V-maf musculoaponeurotic fibrosarcoma oncogene homolog B.