Implications of discoveries from genome-wide association studies in current cardiovascular practice

Table 5 Single nucleotide polymorphisms associated with triglycerides identified through genome-wide association studies

Chromosome	Strongest SNP	Studies	Sample size	MAF (average)	β	Pvalue	Proximal gene	Ref.
1	rs1167998	62 704 220	14 268	32	-0.091	2.0 × 10-12	DOCK7	[27]
	rs10889353	62 890 784	14 337	32	-0.085	8.2 × 10-11		[27]
1	rs11591147	55 278 235	16 826	2	-0.09	< 5 × 10-8	PCSK9	[31]
1	rs12042319	62 822 407	4267	34		3.2 × 10-7	ANGPTL3	[34]
	rs10889353	62 890 784	16 831	33	-0.03	< 5 × 10-8		[31]
	rs10889353	62 890 784	8993	14	-0.13	2.0 × 10-9		[37]
	rs12130333	62 964 365	21 312	22	-0.11	2.0 × 10-8		[29]
	rs10889353	62 890 784	19 834	33	-0.05	3.0 × 10-7		[30]
	rs1748195	62 822 181	18 243			1.7 × 10-10		[20]
	rs2131925	62 798 530	> 100 000	32	-4.94	9.0 × 10-43		[28]
1	rs4846914	228 362 314	21 312	40	0.08	7.0 × 10-15	GALNT2	[28]
2	rs6754295	21 059 688	14 338	25	-0.077	2.5 × 10-8	APOB	[27]
	rs673548	21 091 049	12 694	76	0.086	1.1 × 10-8		[27]
	rs673548	21 091 049	16 797	21	-0.04	< 5 × 10-8		[31]
	rs693	21 085 700	21 312	48	0.12	1.0 × 10-21		[29]
	rs7557067	21 061 717	19 840	22	-0.08	9.0 × 10-12		[30]
	rs1042034	21 078 786	> 100 000	22	-5.99	1.0 × 10-45		[28]
2	rs780094	27 594 741	2659	35		3.7 × 10-8	GCKR	[38]
	rs780094	27 594 741	4267	39		8.1 × 10-14		[34]
	rs1260326	27 584 444	8684	40		1.5 × 10-15		[20]
	rs780094	27 594 741	18 243			6.1 × 10-32		[20]
	rs780094	27 594 741	17 790	63	-0.103	3.1 × 10-20		[27]
	rs1260326	27 584 444	6382	41	0.07	1.3 × 10-16		[32]
	rs1260326	27 584 444	16 650	41	0.07	< 5 × 10-8		[31]
	rs1260326	27 584 444	8993	45	-0.101	1.1 × 10-11		[37]
	rs780094	27 594 741	21 312	34	0.13	3.0 × 10-14		[29]
	rs1260326	27 584 444	19 840	45	0.12	2.0 × 10-31		[30]
	rs1260326	27 584 444	5592	40	0.06	1.8 × 10-7		[36]
	rs1260326	27 584 444	> 100 000	41	8.76	6.0 × 10-133		[28]
2	rs10195252	165 221 337	> 100 000	40	-2.01	2.0 × 10-10	COBLL1	[28]
3	rs645040	137 409 312	> 100 000	22	-2.22	3.0 × 10-8	MSL2L1	[28]
4	rs442177	88 249 285	> 100 000	41	-2.25	9.0 × 10-12	KLHL8	[28]
5	rs9686661	55 897 543	> 100 000	20	2.57	1.0 × 10-10	MAP3K1	[28]
6	rs2076530	32 471 794	16 829	43	0.03	< 5 × 10-8	BTNL2	[31]
6	rs2247056	31 373 469	> 100 000	25	-2.99	2.0 × 10-15	HLA	[28]
7	rs13238203	71 767 603	> 100 000	4	-7.91	1.0 × 10-9	TYW1B	[28]
7	rs17145738	72 620 810	2758 + 18 554	13	-0.14	7.0 × 10-22	BCL7B, TBL2, MLXIPL	[29]
							TBL2
	rs11974409	72 627 326	5592	20	-0.08	5.7 × 10-9	MLXIPL	[36]
	rs10551921	107 998 852	5592	20	-0.08	1.3 × 10-8		[36]
7	rs2240466	72 494 205	12 680	87	0.137	1.1 × 10-12	MLXIPL	[27]
	rs11974409	72 627 326	16 839	19	-0.04	< 5 × 10-8		[31]
	rs714052	72 502 805	19 840	12	-0.16	3.0 × 10-15		[30]
	rs17145738	72 620 810	18 243			2.0 × 10-12		[20]
	rs17145738	72 620 810	> 100 000	12	-9.32	6.0 × 10-58		[28]
7	rs4731702	130 083 924	16 714	49	-0.03	< 5 × 10-8	KLF14	[31]
7	rs17145713	72 542 746	5592	20	-0.09	5.3 × 10-10	BAZ1B	[36]
8	rs11776767	10 721 339	> 100 000	37	2.01	1.0 × 10-8	PINX1	[28]
8	rs1495741	18 317 161	> 100 000	22	2.85	5.0 × 10-14	NAT2	[28]
8	rs2083637	19 909 455	14 344	26	-0.107	1.0 × 10-14	LPL	[27]
	rs10096633	19 875 201	12 708	88	0.174	1.9 × 10-18		[27]
	rs12678919	19 888 502	19 840	10	-0.25	2.0 × 10-41		[30]
	rs10096633	19 875 201	8993	12	-0.169	9.3 × 10-14		[37]
	rs331	19 864 685	5592	25	-0.08	1.7 × 10-11		[36]
	rs12678919	19 888 502	> 100 000	12	-13.64	2.0 × 10-115		[28]
8	rs17482753	19 876 926	2652	11		4.9 × 10-7	LPL	[38]
	rs17482753	19 876 926	1636	10		1.2 × 10-9		[34]
	rs17482753	19 876 926	1636 + 2631			5.2 × 10-15		[34]
	rs6993414	19 947 198	8684	46		1.4 × 10-13		[20]
	rs10503669	19 891 970	4267			3.9 × 10-22		[20]
	rs328	19 864 004	6382	11	-0.09	4.7 × 10-11	Intergenic, PPP1R3B, LPL	[32]
	rs331	19 864 685	6382	28	-0.06	1.7 × 10-9		[32]
	rs328	19 864 685	16 812	11	-0.09	< 5 × 10-8	LPL	[31]
	rs328	19 864 004	21 242	9	-0.19	2.0 × 10-28		[29]
8	rs6982636	126 548 497	16 765	47	-0.03	< 5 × 10-8	TRIB1	[31]
	rs17321515	12 655 591	21 242	49	-0.08	4.0 × 10-17		[29]
	rs2954029	126 560 154	8684	56		2.8 × 10-8		[20]
	rs17321515	12 655 591	14 176			7.0 × 10-13		[20]
	rs2954029	126 560 154	19 840	44	-0.11	3.0 × 10-19		[30]
	rs2954029	126 560 154	> 100 000	47	-5.64	3.0 × 10-55		[28]
8	rs3916027	19 869 148	5592	27	-0.08	1.0 × 10-10	SLC18A1	[36]
8	rs7819412	11 082 571	33 336	48	-0.04	3.0 × 10-8	XKR6-AMAC1L2	[30]
10	rs10761731	64 697 616	> 100 000	43	-2.38	3.0 × 10-12	JMJD1C	[28]
10	rs2068888	94 829 632	> 100 000	46	-2.28	2.0 × 10-8	CYP26A1	[28]
11	rs12272004	116 108 934	12 622	7	-0.181	5.4 × 10-13	APO (A1/A4/A5/C3)	[27]
	rs6589566	116 157 633	1636	6		1.5 × 10-11		[34]
	rs6589566	116 157 633	1636 + 2631			3.7 × 10-12		[34]
	rs964184	116 154 127	8684	12		1.5 × 10-16		[20]
	rs12286037	116 157 417	18 422			1.0 × 10-26		[20]
	rs3135506	116 167 617	6382	6	0.13	5.5 × 10-12		[32]
	rs662799	116 168 917	6382	6	0.14	2.9 × 10-15		[32]
	rs3135506	116 167 617	16 804	6	0.14	< 5 × 10-8		[31]
	rs7350481	116 091 493	8993	43	0.24	1.4 × 10-49		[37]
	rs28927680	116 124 283	21 312	7	0.26	2.0 × 10-17		[29]
	rs964184	116 154 127	19 840	14	0.3	4.0 × 10-62		[30]
	rs651821	116 167 789	5592	6	0.21	8.8 × 10-21	APOA1	[36]
	rs964184	116 154 127	> 100 000	13	16.95	7.0 × 10-240		[28]
11	rs174547	61 327 359	38 846	33	0.06	2.0 × 10-14	FADS1-S3	[30]
	rs174546	61 326 406	> 100 000	34	3.82	5.0 × 10-24		[28]
11	rs6589565	116 145 447	5592	7	0.19	4.5 × 10-20	BUD13	[36]
11	rs2075290	116 158 506	5592	7	0.19	6.6 × 10-20	ZNF259	[36]
12	rs7307277	123 041 109	16 771	34	-0.04	< 5 × 10-8	CCDC92/DNAH10/	[31]
							ZNF664
12	rs11613352	-	> 100 000	23	-2.7	4.0 × 10-10	LRP1	[28]
15	rs2412710	40 471 079	> 100 000	2	7	2.0 × 10-8	CAPN3	[28]
15	rs2929282	42 033 223	> 100 000	5	5.13	2.0 × 10-11	FRMD5	[28]
15	rs4775041	56 461 987	8684	67		7.3 × 10-5	LIPC	[20]
	rs4775041	56 461 987	17 104			1.6 × 10-8		[20]
16	Rs11649653	30 825 988	> 100 000	40	-2.13	3.0 × 10-8	CTF1	[28]
16	rs1800775	55 552 737	16 779	49	-0.03	< 5 × 10-8	CETP	[31]
19	rs157580	50 087 106	16 160	33	-0.069	1.2 × 10-8	TOMM40-APOE	[27]
	rs439401	50 106 291	11 885	68	0.086	1.8 × 10-9		[27]
19	rs16996148	19 519 472	21 312	10	-0.1	4.0 × 10-9	NCAN, CILP2, PBX4	[29]
	rs10401969	19 268 718	8684	8		2.3 × 10-7		[20]
	rs16996148	19 519 472	18 391			2.5 × 10-9		[20]
	rs17216525	46 471 516	19 840	7	-0.11	4.0 × 10-11		[30]
	rs12610185	19 582 722	5592	9	-0.1	5.6 × 10-7		[36]
19	rs439401	50 106 291	16 638	35	-0.04	< 5 × 10-8	APOC1-APOE	[31]
	rs439401	50 106 291	> 100 000	36	-5.5	1.0 × 10-30	APOE	[28]
19	rs2304128	19 607 151	5592	9	-0.1	3.2 × 10-7	GMI	[36]
20	rs6065906	43 987 422	16 810	48	0.04	< 5 × 10-8	PLPT	[31]
	rs7679	44 009 909	38 561	19	0.07	7.0 × 10-11		[30]
22	rs5756931	36 875 979	> 100 000	40	-1.54	4.0 × 10-8	PLA2G6	[28]

β: Estimated mean; DOCK7: Dedicator of cytokinesis 7; PCSK9: Proprotein convertase subtilisin/kexin type 9; GALNT2: N-acetylgalactosaminyltransferase 2; ANGPTL3: Angiopoietin-like 3; APOB: Apolipoprotien B; GCKR: Glucokinase (hexokinase 4) regulator; COBLL1: COBL-like 1; MSL2L1: Male-specific lethal 2 homolog; KLHL8: Kelch-like 8; MAP3K1: Mitogen-activated protein kinase kinase kinase 1; BTNL2: Butyrophilin-like 2 (MHC class II associated); HLA: Major histocompatibility complex; TYW1B: tRNA-yW synthesizing protein 1 homolog B; TBL2: Transducin (β)-like 2; BCL7B: B-cell CLL/lymphoma 7B; TBL2: Transducin (β)-like 2; MLXIPL: MLX interacting protein-like; KLF14: Kruppel-like factor 14; BAZ1B: Bromodomain adjacent to zinc finger domain 1B; PINX1: PIN2/TERF1 interacting, telomerase inhibitor 1; NAT2: N-acetyltransferase 2 (arylamine N-acetyltransferase); LPL: Lipoprotein lipase; PP1R3B: Protein phosphatase 1, regulatory (inhibitor) subunit 3B; TRIB1: Tribbles homolog 1; SLC18A1: Solute carrier family 18 (vesicular monoamine) member 1; XKR6: XK Kell blood group complex subunit-related family member 6; AMAC1L2: Acyl-malonyl condensing enzyme 1-like 2; JMJD1C: Jumonji domain containing 1C; CYP26A1: Cytochrome P450 family 26 subfamily A polypeptide 1; APOA1: Apolipoprotein A-I; FADS: Fatty acid desaturase; CCDC92: Coiled-coil domain containing 92; DNAH10: Dynein axonemal heavy chain 10; ZNF664: Zinc finger protein 664; LRP1: Low density lipoprotein receptor-related protein 1; CAPN3: Calpain 3, (p94); FRMD5: FERM domain containing 5; LIPC: Hepatic lipase; CTF1: Cardiotrophin 1; CETP: Cholesteryl ester transfer protein plasma; TOMM40: Translocase of outer mitochondrial membrane 40 homolog; APOE: Apolipoprotien E; NCAN: Nucleoporin 214 kDa; CILP2: Cartilage intermediate layer protein 2; PBX4: Pre-B-cell leukemia homeobox 4; GMIP: GEM interacting protein; PLPT: Palmitoyl-protein thioesterase 1; PLA2G6: Phospholipase A2, group VI (cytosolic, calcium-independent); SNP: Single nucleotide polymorphisms; MAF: Minor allele frequency.