Non-invasive detection of vulnerable coronary plaque

doi:10.4330/wjc.v3.i7.219

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Jul 26, 2011 (publication date) through Dec 17, 2024

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Guidelines Clinical Practice

World J Cardiol. Jul 26, 2011; 3(7): 219-229
Published online Jul 26, 2011. doi: 10.4330/wjc.v3.i7.219

Table 2 Selected molecular imaging agents in cardiovascular disease

Biological process	Agent	Target	Imaging platform
Plaque rupture/thrombosis	Gadolinium carrying perfluorocarbon and peptides (EP-2104R)	Fibrin	MRI
	Phage display nanoparticles generated by CEST ^99mTc-apcitide	Glycoprotein IIb/IIIa receptor	SPECT
Inflammation/apoptosis	MNP + specific antibodies	E-selectin	MRI
	Monocrystalline iron oxide	ICAM/VCAM	PET
	Cross-linked iron oxide ¹⁸FDG	Macrophages glucose transporter-1, hexokinase	SPECT
	^99mTc-annexin	Phosphatidylserine/caspases	SPECT
	^99mTc-interleukin-2	Lymphocytes
Angiogenesis	MNP + specific antibody ^99mNC100692	VCAM-1/integrin α_vβ₃	MRI
Myocardial infarction	MNP ¹¹¹Indium oxide	Stem cell labeling	MRI/SPECT

MNP: Paramagnetic nanoparticle; CEST: Chemical exchange saturation transfer; MRI: Magnetic resonance imaging; SPECT: Single photon emission computed tomography; PET: Positron emission tomography; ICAM: Intercellular adhesion molecule; VCAM: Vascular cell adhesion molecule;

¹⁸FDG: Fluorine-18 fluorodeoxyglucose.

Citation: Sharif F, Lohan DG, Wijns W. Non-invasive detection of vulnerable coronary plaque. World J Cardiol 2011; 3(7): 219-229
URL: https://www.wjgnet.com/1949-8462/full/v3/i7/219.htm
DOI: https://dx.doi.org/10.4330/wjc.v3.i7.219