Angiotensin-converting enzyme and bradykinin gene polymorphisms and cough: A meta-analysis

Table 2 Odds ratios and heterogeneity results for the genetic contrasts of ACE I/D and bradykinin B₂ receptor gene polymorphisms

	Genetic contrast	Population	Studies	Random effects [OR (95% CI)]	P value Q test	Z
Angiotensin converting enzyme	D vs I	All	7	1.15 (0.87-1.52)	0.259	0.231
		Caucasians	2	0.90 (0.60-1.35)	0.799	0.612
		East Asians	5	1.49 (1.11-2.02)	0.226	0.009
	DD vs (DI + II)	All	11	0.85 (0.67-1.06)	0.005	0.153
		Caucasians	3	1.14 (0.74-1.76)	0.716	0.563
		East Asians	8	0.76 (0.58-0.99)	0.003	0.042
	(DD + II) vs II	All	11	1.22 (0.91-1.64)	0.052	0.133
		Caucasians	3	0.84 (0.46-1.55)	0.560	0.553
		East Asians	8	1.35 (0.91-2.00)	0.027	0.075
	DD vs II	All	11	0.79 (0.62-1.01)	0.008	0.058
		Caucasians	3	1.12 (0.69-1.83)	0.614	0.626
		East Asians	8	0.70 (0.53-0.93)	0.006	0.013
	ID vs (DD + II)	All	11	0.95 (0.80-1.22)	0.936	0.354
		Caucasians	3	0.97 (0.63-1.50)	0.889	0.900
		East Asians	8	0.94 (0.79-1.13)	0.786	0.342
Bradykinin B2 receptor -58T/C	T vs C	East Asians	2	2.29 (1.42-3.68)	0.298	0.001
	TT vs (TC + CC)	East Asians	3	1.47 (0.56-3.85 )	0.002	0.467
	CC vs (TC + TT)	East Asians	3	0.90 (0.66-1.24)	0.661	0.507
	TC vs (TT + CC)	East Asians	3	1.08 (0.87-1.34)	0.947	0.477